Killer Cell Lectin-Like Receptor Subfamily C, Member 3 (KLRC3) (AA 132-241) antibody

Details for Product No. ABIN395957
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Antigen
Synonyms Klrc2, Nkg2e, KLRC2, NKG2-C, NKG2-E, NKG2E
Epitope
AA 132-241
(3), (2)
Reactivity
Human
(7)
Host
Mouse
(4), (3)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(7), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN395957
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Immunogen KLRC3 (NP_002252, 132 a.a. ~ 241 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D5
Isotype IgG2a kappa
Specificity KLRC3 (NP_002252, 132 a.a. ~ 241 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KLRC3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 27012 DA
Gene ID 12406
NCBI Accession NP_002252
Research Area Cell Structure, Cancer
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Killer Cell Lectin-Like Receptor Subfamily C, Member 3 (KLRC3) (AA 132-241) antibody Detection limit for recombinant GST tagged KLRC3 is approximately 0.3 ng/mL as a capture antibody.
Background publications Lazetic, Chang, Houchins et al.: "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 11, pp. 4741-5, 1996 (PubMed).

Plougastel, Trowsdale: "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes." in: Genomics, Vol. 49, Issue 2, pp. 193-9, 1998 (PubMed).

Glienke, Sobanov, Brostjan et al.: "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex." in: Immunogenetics, Vol. 48, Issue 3, pp. 163-73, 1998 (PubMed).

Bellón, Heredia, Llano et al.: "Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 7, pp. 3996-4002, 1999 (PubMed).

Shum, Flodin, Muir et al.: "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 1, pp. 240-52, 2001 (PubMed).

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