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B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) antibody

Details for Product No. ABIN395972
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Antigen
Synonyms 2810047E18Rik, BCL-11A, Ctip1, D930021L15Rik, Evi9, Evi9a, Evi9b, Evi9c, mKIAA1809, BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, EVI9, HBFQTL5, ZNF856, bcl11a, wu:fi09f10, zgc:136898
Reactivity
Human
(50), (18), (18), (13), (1), (1), (1), (1)
Host
Mouse
(46), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(43), (18), (10), (9), (7), (4), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN395972
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen BCL11A (NP_060484, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D9
Isotype IgG2a kappa
Specificity BCL11A (NP_060484, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BCL11A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 91197 DA
Gene ID 12406
UniProt NP_060484
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) antibody Western Blot analysis of BCL11A expression in transfected 293T cell line by BCL11A monoclonal antibody (M03), clone 3D9. Lane 1: BCL11A transfected lysate(26.865 KDa). Lane 2: Non-transfected lysate.
Background publications Xu, Sankaran, Ni et al.: "Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6." in: Genes & development, Vol. 24, Issue 8, pp. 783-98, 2010 (PubMed).

Nguyen, Joly, Bardel et al.: "The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients." in: Blood cells, molecules & diseases, Vol. 45, Issue 2, pp. 124-7, 2010 (PubMed).

Deambrogi, De Paoli, Fangazio et al.: "Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia." in: American journal of hematology, Vol. 85, Issue 7, pp. 541-4, 2010 (PubMed).

Agueli, Cammarata, Salemi et al.: "14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a." in: American journal of hematology, Vol. 85, Issue 8, pp. 575-8, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN395972
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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