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B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-89) antibody

Details for Product No. ABIN395972, Supplier: Log in to see
Antigen
  • 2810047E18Rik
  • BCL-11A
  • Ctip1
  • D930021L15Rik
  • Evi9
  • Evi9a
  • Evi9b
  • Evi9c
  • mKIAA1809
  • BCL11A-L
  • BCL11A-S
  • BCL11A-XL
  • BCL11a-M
  • CTIP1
  • EVI9
  • HBFQTL5
  • ZNF856
  • bcl11a
  • wu:fi09f10
  • zgc:136898
Epitope
AA 1-89
27
19
8
6
5
4
2
2
2
1
1
1
1
1
Reactivity
Human
89
27
27
3
3
2
2
2
1
1
1
1
Host
Mouse
78
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
73
31
18
11
10
9
4
3
3
2
1
1
Supplier
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Immunogen BCL11A (NP_060484, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D9
Isotype IgG2a kappa
Specificity BCL11A (NP_060484, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BCL11A (BCL11A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 91197 DA
Gene ID 12406
NCBI Accession NP_060484
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (AA 1-89) antibody (ABIN395972) Western Blot analysis of BCL11A expression in transfected 293T cell line by BCL11A mo...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Agueli, Cammarata, Salemi et al.: "14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a." in: American journal of hematology, Vol. 85, Issue 8, pp. 575-8, 2010 (PubMed).

Deambrogi, De Paoli, Fangazio et al.: "Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia." in: American journal of hematology, Vol. 85, Issue 7, pp. 541-4, 2010 (PubMed).

Nguyen, Joly, Bardel et al.: "The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients." in: Blood cells, molecules & diseases, Vol. 45, Issue 2, pp. 124-7, 2010 (PubMed).

Xu, Sankaran, Ni et al.: "Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6." in: Genes & development, Vol. 24, Issue 8, pp. 783-98, 2010 (PubMed).