Integrator Complex Subunit 6 (INTS6) antibody

Details for Product No. ABIN395973
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Antigen
Synonyms DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, Ddx26, Notch2l, AI480962, 2900075H24Rik, LRRGT00024, INTS6, ints6-b
Reactivity
Human
(5), (1), (1), (1)
Host
Mouse
(3), (3)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(6), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN395973
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen DDX26 (NP_036273, 779 a.a. ~ 888 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D9
Isotype IgG1 kappa
Specificity DDX26 (NP_036273, 779 a.a. ~ 888 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DDX26
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 100390 DA
Gene ID 12406
UniProt NP_036273
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Integrator Complex Subunit 6 (INTS6) antibody Immunoperoxidase of monoclonal antibody to DDX26 on formalin-fixed paraffin-embedded human testis (antibody concentration 3 µg/mL).
Background publications Röpke, Buhtz, Böhm et al.: "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer." in: Oncogene, Vol. 24, Issue 44, pp. 6667-75, 2005 (PubMed).

Baillat, Hakimi, Näär et al.: "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." in: Cell, Vol. 123, Issue 2, pp. 265-76, 2005 (PubMed).

Hernández, Papadopoulos, Almeida: "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions." in: Cancer genetics and cytogenetics, Vol. 163, Issue 1, pp. 91-2, 2005 (PubMed).

Buchsbaum, Morris, Bochard et al.: "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle." in: Oncogene, Vol. 26, Issue 35, pp. 5132-44, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Hosts (3), (3)
Reactivities (5), (1), (1), (1)
Applications (6), (3), (2), (2)
Epitopes (2), (1)
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