Apolipoprotein H (Beta-2-Glycoprotein I) (APOH) (AA 236-346) antibody

Details for Product No. ABIN395997
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Antigen
Synonyms apoh, APOH, LOC100227913, B2GPI, beta-2-GPI, beta2-GPI, B2G1, B2GP1, BG
Epitope
AA 236-346
(9), (5), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(70), (21), (20), (18), (17), (3), (1)
Host
Mouse
(44), (17), (16), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (32), (20), (13), (12), (10), (10), (5), (3), (3), (3), (2), (2), (2)
Pubmed 5 references available
Quantity 200 µL
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Catalog No. ABIN395997
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Immunogen APOH (NP_000033, 236 a.a. ~ 346 a.a) partial recombinant protein with GST tag.
Clone 3F10
Isotype IgM kappa
Specificity APOH (NP_000033, 236 a.a. ~ 346 a.a) partial recombinant protein with GST tag.
Purification Purified
Alternative Name APOH
Background Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
Synonyms: B2G1, BG apolipoprotein H (beta-2-glycoprotein I)
Molecular Weight 38298 DA
Gene ID 350
NCBI Accession NP_000033
Research Area Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.

Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Apolipoprotein H (Beta-2-Glycoprotein I) (APOH) (AA 236-346) antibody APOH monoclonal antibody (M01A), clone 3F10 Western Blot analysis of APOH expression in HL-60.
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Pozzi, Banzato, Bettin et al.: "Chemical synthesis and characterization of wild-type and biotinylated N-terminal domain 1-64 of beta2-glycoprotein I." in: Protein science : a publication of the Protein Society, Vol. 19, Issue 5, pp. 1065-78, 2010 (PubMed).

Alard, Gaillard, Daridon et al.: "TLR2 is one of the endothelial receptors for beta 2-glycoprotein I." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1550-7, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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