Apolipoprotein H (Beta-2-Glycoprotein I) (APOH) antibody

Antigen: Apolipoprotein H (Beta-2-Glycoprotein I) (APOH)

Synonyms: BG, B2G1, APOH, MGC140489, apoh, LOC100227913

Clonality: Monoclonal (3F10)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN395997

Additional Information

Alternative name: APOH

Gene ID: 350

UniProt: NP_000033

Immunogen: APOH (NP_000033, 236 a.a. ~ 346 a.a) partial recombinant protein with GST tag.

Isotype: IgM kappa

Clone: 3F10

Description: Other names: B2G1, BG apolipoprotein H (beta-2-glycoprotein I)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: APOH (NP_000033, 236 a.a. ~ 346 a.a) partial recombinant protein with GST tag.

Molecular Weight: 38298 DA

Comments:

Background: Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Images

APOH monoclonal antibody (M01A), clone 3F10 Western Blot analysis of APOH expression in HL-60 ( Cat # L014V1 ).

Publications

Product: Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Pozzi, Banzato, Bettin et al.: "Chemical synthesis and characterization of wild-type and biotinylated N-terminal domain 1-64 of beta2-glycoprotein I." in: Protein science : a publication of the Protein Society, Vol. 19, Issue 5, pp. 1065-78, 2010 (PubMed).

Alard, Gaillard, Daridon et al.: "TLR2 is one of the endothelial receptors for beta 2-glycoprotein I." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1550-7, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).