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Fatty Acid Synthase antibody (FASN) (AA 1-440)

Details for Product anti-FASN Antibody No. ABIN396013, Supplier: Log in to see
Antigen
  • A630082H08Rik
  • anon-EST:Posey43
  • anon-EST:Posey235
  • anon-WO0138581.1
  • BcDNA:gh07626
  • BcDNA:GH07626
  • Cgl0836
  • dFAS
  • Dmel\\CG3523
  • DM_7295848
  • fas
  • FAS
  • FASN
  • Fatty acid synthase
  • fj34h12
  • OA-519
  • SDR27X1
  • wu:fj34h12
Alternatives
anti-Human Fatty Acid Synthase antibody for Western Blotting
Epitope
AA 1-440
14
14
13
12
12
8
8
5
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
125
55
36
7
3
3
2
2
1
1
1
Host
Mouse
97
37
7
Clonality (Clone)
Monoclonal ()
Conjugate
This Fatty Acid Synthase antibody is un-conjugated
3
3
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
103
43
36
29
25
15
15
11
5
4
2
2
1
1
1
Supplier
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Immunogen FASN (AAH07909, 1 a.a. ~ 440 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F2-1F3
Isotype IgG1 kappa
Specificity FASN (AAH07909, 1 a.a. ~ 440 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name FASN (FASN Antibody Abstract)
Background The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Synonyms: FAS, MGC14367, MGC15706, OA519 fatty acid synthase
Molecular Weight 273400 DA
Gene ID 2194
Research Area Cancer, Cell Structure
Pathways AMPK Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Fatty Acid Synthase antibody (FASN) (AA 1-440) (ABIN396013) Immunofluorescence of monoclonal antibody to FASN on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-Fatty Acid Synthase antibody (FASN) (AA 1-440) (ABIN396013) anti-Fatty Acid Synthase (FASN) (AA 1-440) antibody (Image 2)
Background publications Nguyen, Ma, Chavarro, Freedman, Lis, Fedele, Fiore, Qiu, Fiorentino, Finn, Penney, Eisenstein, Schumacher, Mucci, Stampfer, Giovannucci, Loda: "Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 28, Issue 25, pp. 3958-64, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Zeng, Biernacka, Holly, Jarrett, Morrison, Morgan, Winters, Foulstone, Shield, Perks: "Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase." in: Endocrine-related cancer, Vol. 17, Issue 2, pp. 539-51, 2010 (PubMed).

Fernandez-Real, Menendez, Moreno-Navarrete, Blüher, Vazquez-Martin, Vázquez, Ortega, Diéguez, Frühbeck, Ricart, Vidal-Puig: "Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance." in: Diabetes, Vol. 59, Issue 6, pp. 1506-11, 2010 (PubMed).