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WAP Four-Disulfide Core Domain 2 (WFDC2) (AA 31-125) antibody

Details for Product No. ABIN396057, Supplier: Log in to see
Antigen
  • WFDC3
  • WFDC2
  • si:ch211-153a8.3
  • EDDM4
  • HE4
  • WAP5
  • dJ461P17.6
  • 1600023A02Rik
  • re4
  • CE4
  • BE-20
Epitope
AA 31-125
17
10
5
5
3
2
2
2
2
2
1
1
1
1
Reactivity
Human
121
18
18
6
3
Host
Mouse
71
45
21
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
14
8
7
2
2
2
2
2
2
2
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
82
65
22
20
15
8
6
3
2
2
2
1
1
Supplier
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Immunogen WFDC2 (AAH46106, 31 a.a. ~ 125 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F9
Isotype IgG2b kappa
Specificity WFDC2 (AAH46106, 31 a.a. ~ 125 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WFDC2 (WFDC2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12993 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-WAP Four-Disulfide Core Domain 2 (WFDC2) (AA 31-125) antibody (ABIN396057) Detection limit for recombinant GST tagged WFDC2 is approximately 0.03 ng/mL as a cap...
Background publications Hellstrom, Heagerty, Swisher et al.: "Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms." in: Cancer letters, Vol. 296, Issue 1, pp. 43-8, 2010 (PubMed).

Stein, Hua, Lee et al.: "Voxelwise genome-wide association study (vGWAS)." in: NeuroImage, Vol. 53, Issue 3, pp. 1160-74, 2010 (PubMed).

Xi, LinLin, Ye: "Human epididymis protein 4 is a biomarker for transitional cell carcinoma in the urinary system." in: Journal of clinical laboratory analysis, Vol. 23, Issue 6, pp. 357-61, 2009 (PubMed).

Montagnana, Lippi, Ruzzenente et al.: "The utility of serum human epididymis protein 4 (HE4) in patients with a pelvic mass." in: Journal of clinical laboratory analysis, Vol. 23, Issue 5, pp. 331-5, 2009 (PubMed).

Li, Dowdy, Tipton et al.: "HE4 as a biomarker for ovarian and endometrial cancer management." in: Expert review of molecular diagnostics, Vol. 9, Issue 6, pp. 555-66, 2009 (PubMed).