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Details for Product No. ABIN396057

WAP Four-Disulfide Core Domain 2 (WFDC2) antibody

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Antigen
Synonyms EDDM4, HE4, WAP5, dJ461P17.6, 1600023A02Rik, re4, CE4, BE-20, WFDC2, WFDC3, si:ch211-153a8.3
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396057
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen WFDC2 (AAH46106, 31 a.a. ~ 125 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F9
Isotype IgG2b kappa
Specificity WFDC2 (AAH46106, 31 a.a. ~ 125 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WFDC2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12993 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Li, Dowdy, Tipton et al.: "HE4 as a biomarker for ovarian and endometrial cancer management." in: Expert review of molecular diagnostics, Vol. 9, Issue 6, pp. 555-66, 2009 (PubMed).

Montagnana, Lippi, Ruzzenente et al.: "The utility of serum human epididymis protein 4 (HE4) in patients with a pelvic mass." in: Journal of clinical laboratory analysis, Vol. 23, Issue 5, pp. 331-5, 2009 (PubMed).

Xi, LinLin, Ye: "Human epididymis protein 4 is a biomarker for transitional cell carcinoma in the urinary system." in: Journal of clinical laboratory analysis, Vol. 23, Issue 6, pp. 357-61, 2009 (PubMed).

Stein, Hua, Lee et al.: "Voxelwise genome-wide association study (vGWAS)." in: NeuroImage, Vol. 53, Issue 3, pp. 1160-74, 2010 (PubMed).

Hellstrom, Heagerty, Swisher et al.: "Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms." in: Cancer letters, Vol. 296, Issue 1, pp. 43-8, 2010 (PubMed).

Alternatives for antigen "WAP Four-Disulfide Core Domain 2 (WFDC2)", type "Antibodies"
Hosts (38), (6), (5), (1)
Reactivities (39), (13), (13), (2), (1)
Applications (24), (24), (19), (15), (6), (5), (2), (1), (1)
Conjugates (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (5), (5), (2), (1)
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