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Acyl-CoA Synthetase Long-Chain Family Member 1 (Acsl1) (AA 48-146) antibody

Details for Product No. ABIN396082, Supplier: Log in to see
Antigen
  • zgc:110081
  • ACS1
  • FACL1
  • FACL2
  • LACS
  • LACS1
  • LACS2
  • Acas
  • Acas1
  • Acs
  • FACS
  • Facl2
  • ACS
  • COAA
  • CER8
  • ECERIFERUM 8
  • LONG-CHAIN ACYL-COA SYNTHASE 1
  • T8I13.8
  • F13F21.14
  • F13F21_14
  • LATERAL ROOT DEVELOPMENT 2
  • LRD2
  • long-chain acyl-CoA synthetase 2
Epitope
AA 48-146
17
15
10
6
3
2
1
1
Reactivity
Human
65
31
31
4
3
3
3
1
1
Host
Mouse
62
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
52
23
11
8
5
2
1
Supplier
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Immunogen ACSL1 (NP_001986, 48 a.a. ~ 146 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3G4
Isotype IgG2a kappa
Specificity ACSL1 (NP_001986, 48 a.a. ~ 146 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACSL1 (Acsl1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 77943 DA
Gene ID 12406
NCBI Accession NP_001986
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Acyl-CoA Synthetase Long-Chain Family Member 1 (Acsl1) (AA 48-146) antibody (ABIN396082) Detection limit for recombinant GST tagged ACSL1 is approximately 0.3 ng/mL as a capt...
Background publications Phillips, Goumidi, Bertrais et al.: "Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome." in: Journal of lipid research, Vol. 51, Issue 7, pp. 1793-800, 2010 (PubMed).

Lu, Dollé, Imholz et al.: "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations." in: Journal of lipid research, Vol. 49, Issue 12, pp. 2582-9, 2008 (PubMed).

Soupene, Kuypers: "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains." in: BMC molecular biology, Vol. 7, pp. 21, 2006 (PubMed).

Kahn, Alquier, Carling et al.: "AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism." in: Cell metabolism, Vol. 1, Issue 1, pp. 15-25, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).