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Details for Product No. ABIN396085

Homogentisate 1,2-Dioxygenase (HGD) (Met10) antibody

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Synonyms AKU, HGO, Hgo, aku, hgo, CG4779, Dmel\\CG4779, PSPTO3551, DDBDRAFT_0185702, DDBDRAFT_0191461, DDB_0185702, DDB_0191461
»Alternatives Met10
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA
Pubmed 5 references available
Catalog no. ABIN396085
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen HGD (NP_000178, 377 a.a. ~ 446 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3G4
Isotype IgG2b kappa
Specificity HGD (NP_000178, 377 a.a. ~ 446 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HGD
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 49973 DA
Gene ID 12406
UniProt NP_000178
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Abdulrazzaq, Ibrahim, Al-Khayat et al.: "R58fs mutation in the HGD gene in a family with alkaptonuria in the UAE." in: Annals of human genetics, Vol. 73, Issue 1, pp. 125-30, 2009 (PubMed).

Vilboux, Kayser, Introne et al.: "Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria." in: Human mutation, Vol. 30, Issue 12, pp. 1611-9, 2009 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

in: (PubMed).

Alternatives for antigen "Homogentisate 1,2-Dioxygenase (HGD)", type "Antibodies"
Hosts (24), (7)
Reactivities (30), (4), (4), (1), (1), (1), (1)
Applications (19), (17), (10), (6), (5), (3), (3), (3), (2), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (1), (1), (1)