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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 611-711) antibody

Details for Product No. ABIN396093, Supplier: Log in to see
Antigen
  • ABC36
  • HHF1
  • HI
  • HRINS
  • MRP8
  • PHHI
  • SUR
  • SUR1
  • SUR1delta2
  • TNDM2
  • D930031B21Rik
  • Sur
  • Sur1
Epitope
AA 611-711
48
36
18
4
4
2
2
1
1
1
Reactivity
Human
48
34
33
19
2
2
2
1
1
1
Host
Mouse
48
15
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
70
46
36
21
18
3
3
2
2
1
1
Supplier
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Immunogen ABCC8 (NP_000343, 611 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3G5
Isotype IgG2a kappa
Specificity ABCC8 (NP_000343, 611 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name ABCC8 (ABCC8 Antibody Abstract)
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described.
Synonyms: ABC36, HI, HRINS, MRP8, PHHI, SUR, SUR1 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Molecular Weight 177022 DA
Gene ID 6833
NCBI Accession NP_000343
Research Area Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (AA 611-711) antibody (ABIN396093) Detection limit for recombinant GST tagged ABCC8 is approximately 0.03 ng/mL as a cap...
Background publications Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Ruchat, Vohl, Weisnagel et al.: "Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism." in: Annals of medicine, Vol. 42, Issue 3, pp. 196-206, 2010 (PubMed).