Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1) antibody

Antigen: Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1)

Synonyms: C21, DC42, IRA1, TBLR1, FLJ12894, RGD1560053, MGC63617, zgc:63617, c21, dc42, ira1, TBL1XR1, MGC110312, wu:fc46g07, CH211-51H4.1

Clonality: Monoclonal (3G7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396109

Additional Information

Alternative name: TBL1XR1

Gene ID: 79718

UniProt: NP_078941

Immunogen: TBL1XR1 (-, 81 a.a. ~ 179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3G7

Description: Other names: C21, DC42, FLJ12894, IRA1, TBLR1 transducin (beta)-like 1X-linked receptor 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TBL1XR1 (-, 81 a.a. ~ 179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 55595 DA

Comments:

Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to TBL1XR1 (AT4163a) on HeLa cell . [antibody concentration 10 ug/ml] TBL1XR1 monoclonal antibody (M01), clone 3G7 Western Blot analysis of TBL1XR1 expression in HeLa ( Cat # L013V1 ).

anti-Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1) antibody (Image 2)

Publications

Product: Ishii, Kurasawa, Wong et al.: "Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 11, pp. 4179-84, 2008 (PubMed).

Perissi, Scafoglio, Zhang et al.: "TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints." in: Molecular cell, Vol. 29, Issue 6, pp. 755-66, 2008 (PubMed).

Parker, An, Barber et al.: "The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1." in: Genes, chromosomes & cancer, Vol. 47, Issue 12, pp. 1118-25, 2008 (PubMed).

Rothenberg, Spergel, Sherrill et al.: "Common variants at 5q22 associate with pediatric eosinophilic esophagitis." in: Nature genetics, Vol. 42, Issue 4, pp. 289-91, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).