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Decorin (DCN) (AA 1-360) antibody

Details for Product No. ABIN396139
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Antigen
Synonyms DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B, DC, mDcn, cscd, dspg2, pg40, pgii, pgs2, slrr1b
Epitope
AA 1-360
(10), (7), (5), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(87), (32), (28), (20), (18), (15), (12), (5), (2), (1)
Host
Mouse
(55), (22), (8), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(69), (39), (19), (15), (10), (4), (4), (4), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396139
450.00 $
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Immunogen DCN (AAH05322, 1 a.a. ~ 360 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3H4-1F4
Isotype IgG2b kappa
Specificity DCN (AAH05322, 1 a.a. ~ 360 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DCN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39747 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Decorin (DCN) (AA 1-360) antibody Immunoperoxidase of monoclonal antibody to DCN on formalin-fixed paraffin-embedded human adrenal gland (antibody concentration 3 µg/mL). Detection limit for recombinant GST tagged DCN is approximately 1 ng/mL as a capture antibody.
anti-Decorin (DCN) (AA 1-360) antibody (2) anti-Decorin (DCN) (AA 1-360) antibody (Image 2)
Background publications Dimasi, Burdon, Hewitt et al.: "Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness." in: Molecular vision, Vol. 16, pp. 562-9, 2010 (PubMed).

Mohan, Gupta, Mehan et al.: "Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts." in: Experimental eye research, Vol. 91, Issue 2, pp. 238-45, 2010 (PubMed).

Swan, Murthi, Rajaraman et al.: "Decorin expression is decreased in human idiopathic fetal growth restriction." in: Reproduction, fertility, and development, Vol. 22, Issue 6, pp. 949-55, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Validation Images
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