Trefoil Factor 1 (TFF1) (AA 1-85) antibody

Details for Product No. ABIN396144
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Antigen
Synonyms ps2, xp1, bcei, hps2, hp1.a, pnr-2, d21s21, TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2, Bcei, PS2, Ps2, p1, p1-a, tff1, xP1, xp1-L
Epitope
AA 1-85
(8), (8), (7), (7), (5), (1), (1), (1)
Reactivity
Human
(52), (3), (2)
Host
Mouse
(30), (25)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1)
Application
ELISA, Western Blotting (WB)
(38), (25), (16), (12), (5), (4), (3), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396144
450.00 $
Plus shipping costs $45.00

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Immunogen TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3H5
Isotype IgG1 kappa
Specificity TFF1 (AAH32811, 1 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TFF1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 9150 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yoshida, Kato, Yokoi et al.: "Association of gene polymorphisms with chronic kidney disease in Japanese individuals." in: International journal of molecular medicine, Vol. 24, Issue 4, pp. 539-47, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Rinnert, Hinz, Buhtz et al.: "Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine." in: Cell and tissue research, Vol. 339, Issue 3, pp. 639-47, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Tosco, Monti, Fontanella et al.: "Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 11, pp. 1943-55, 2010 (PubMed).

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