Intercellular Adhesion Molecule 1 (ICAM1) antibody

Antigen: Intercellular Adhesion Molecule 1 (ICAM1)

Synonyms: BB2, CD54, P3.58, Ly-47, Icam-1, MALA-2, MGC6195, ICAM-1, ICAM1, ICAM

Clonality: Monoclonal (3H8-2G6)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396158

Additional Information

Alternative name: ICAM1

Gene ID: 3383

Immunogen: ICAM1 (AAH15969, 1 a.a. ~ 533 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3H8-2G6

Description: Other names: BB2, CD54, P3.58 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ICAM1 (AAH15969, 1 a.a. ~ 533 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 57825 DA

Comments:

Background: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged ICAM1 is approximately 0.1ng/ml as a capture antibody.

Publications

Product: van Buul, van Rijssel, van Alphen et al.: "Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium." in: PLoS ONE, Vol. 5, Issue 6, pp. e11336, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Beckers, Ruven, Haas et al.: "Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism." in: European journal of internal medicine, Vol. 21, Issue 4, pp. 289-92, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Cserti-Gazdewich, Dzik, Erdman et al.: "Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda." in: Malaria journal, Vol. 9, pp. 233, 2010 (PubMed).