Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibody

Details for Product No. ABIN396192
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Synonyms OCRL, wu:fi09g03, zgc:152864, locr, nphl2, ocrl1, inpp5f, INPP5F, LOCR, NPHL2, OCRL-1, OCRL1, 9530014D17Rik, BB143339
AA 146-240
(17), (7), (5), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(65), (19), (14), (1)
(36), (29)
Clonality (Clone)
Monoclonal ()
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(54), (23), (18), (10), (9), (8), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen OCRL (NP_000267, 146 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A6
Isotype IgG2a kappa
Specificity OCRL (NP_000267, 146 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OCRL (OCRL Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 104205 DA
Gene ID 12406
NCBI Accession NP_000267
Research Area Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibody (ABIN396192) Western blot analysis of OCRL over-expressed 293 cell line, cotransfected with OCRL V...
Immunohistochemistry (IHC) image for anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibody (ABIN396192) anti-Oculocerebrorenal Syndrome of Lowe (OCRL) (AA 146-240) antibody (Image 2)
Background publications Swan, Tomasini, Pirruccello et al.: "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3511-6, 2010 (PubMed).

Coutton, Monnier, Rendu et al.: "Development of a multiplex ligation-dependent probe amplification (MLPA) assay for quantification of the OCRL1 gene." in: Clinical biochemistry, Vol. 43, Issue 6, pp. 609-14, 2010 (PubMed).

Cui, Guerriero, Szalinski et al.: "OCRL1 function in renal epithelial membrane traffic." in: American journal of physiology. Renal physiology, Vol. 298, Issue 2, pp. F335-45, 2010 (PubMed).

Coon, Mukherjee, Hanna et al.: "Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4478-91, 2009 (PubMed).

Tosetto, Addis, Caridi et al.: "Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations." in: Pediatric nephrology (Berlin, Germany), Vol. 24, Issue 10, pp. 1967-73, 2009 (PubMed).

Catalog No. ABIN396192
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