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Oculocerebrorenal Syndrome of Lowe (OCRL) antibody

Details for Product No. ABIN396192
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Antigen
Synonyms INPP5F, LOCR, NPHL2, OCRL-1, OCRL1, BB143339, 9530014D17Rik, OCRL, wu:fi09g03, zgc:152864, locr, nphl2, ocrl1, inpp5f
Reactivity
Human
(62), (18), (14), (12), (12), (12)
Host
Mouse
(31), (31)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (30), (19), (12), (10), (9), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396192
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen OCRL (NP_000267, 146 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A6
Isotype IgG2a kappa
Specificity OCRL (NP_000267, 146 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OCRL
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 104205 DA
Gene ID 12406
UniProt NP_000267
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) antibody Western blot analysis of OCRL over-expressed 293 cell line, cotransfected with OCRL Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of OCRL expression in transfected 293T cell line by OCRL monoclonal antibody (M02), clone 4A6. Lane 1: OCRL transfected lysate(103.2 KDa). Lane 2: Non-transfected lysate.
anti-Oculocerebrorenal Syndrome of Lowe (OCRL) antibody (2) anti-Oculocerebrorenal Syndrome of Lowe (OCRL) antibody (Image 2)
Background publications Tosetto, Addis, Caridi et al.: "Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations." in: Pediatric nephrology (Berlin, Germany), Vol. 24, Issue 10, pp. 1967-73, 2009 (PubMed).

Coon, Mukherjee, Hanna et al.: "Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4478-91, 2009 (PubMed).

Cui, Guerriero, Szalinski et al.: "OCRL1 function in renal epithelial membrane traffic." in: American journal of physiology. Renal physiology, Vol. 298, Issue 2, pp. F335-45, 2010 (PubMed).

Coutton, Monnier, Rendu et al.: "Development of a multiplex ligation-dependent probe amplification (MLPA) assay for quantification of the OCRL1 gene." in: Clinical biochemistry, Vol. 43, Issue 6, pp. 609-14, 2010 (PubMed).

Swan, Tomasini, Pirruccello et al.: "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3511-6, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN396192
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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