RAD54 Homolog B (S. Cerevisiae) (RAD54B) antibody

Details for Product No. ABIN396196
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Synonyms RDH54, E130016E03Rik, Fsbp, RGD1306507, fsbp, rdh54, RAD54B, im:7137737, im:7153525
(32), (14), (13), (13), (12), (12), (1)
(33), (2)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(20), (10), (10), (6), (4), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN396196
Quantity 0.1 mg
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Immunogen RAD54B (AAH01965, 801 a.a. ~ 910 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A7
Isotype IgG1 kappa
Specificity RAD54B (AAH01965, 801 a.a. ~ 910 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RAD54B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 102967 DA
Gene ID 12406
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-RAD54 Homolog B (S. Cerevisiae) (RAD54B) antibody Immunofluorescence of monoclonal antibody to RAD54B on HeLa cell (antibody concentration 10 µg/mL). RAD54B monoclonal antibody (M01), clone 4A7 Western Blot analysis of RAD54B expression in HeLa NE.
anti-RAD54 Homolog B (S. Cerevisiae) (RAD54B) antibody (2) anti-RAD54 Homolog B (S. Cerevisiae) (RAD54B) antibody (Image 2)
Background publications McManus, Barrett, Nouhi et al.: "Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3276-81, 2009 (PubMed).

Kweekel, Antonini, Nortier et al.: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, 2009 (PubMed).

McWilliams, Bamlet, de Andrade et al.: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, 2009 (PubMed).

Briggs, Goldstein, McCauley et al.: "Variation within DNA repair pathway genes and risk of multiple sclerosis." in: American journal of epidemiology, Vol. 172, Issue 2, pp. 217-24, 2010 (PubMed).

Liu, Shete, Wang et al.: "Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk." in: Carcinogenesis, Vol. 31, Issue 10, pp. 1762-9, 2010 (PubMed).

Hosts (33), (2)
Reactivities (32), (14), (13), (13), (12), (12), (1)
Applications (20), (10), (10), (6), (4), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (1), (1), (1), (1), (1)
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