Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody

Antigen: Actin, alpha 2, Smooth Muscle, Aorta (ACTA2)

Synonyms: AAT6, ACTSA, Actvs, a-SMA, SMalphaA, 0610041G09Rik, wu:fb63d03, MGC78870, ACTA2, actc1, actsa, MGC89192, MGC127800, ACT-4, DKFZp469E0314, Acta2, asma, acta, cftd, mpfd, nem1, nem2, nem3, acta2, cftd1, cftdm, MGC52636, MGC79039

Clonality: Monoclonal (4A8-2H3)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396199

Additional Information

Alternative name: ACTA2

Gene ID: 59

Immunogen: ACTA2 (AAH17554, 1 a.a. ~ 378 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 4A8-2H3

Description: Other names: ACTSA actin, alpha 2, smooth muscle, aorta

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ACTA2 (AAH17554, 1 a.a. ~ 378 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 42009 DA

Comments:

Background: The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms: AAT6, ACTSA, Actvs, a-SMA, SMalphaA, 0610041G09Rik, wu:fb63d03, MGC78870, ACTA2, actc1, actsa, MGC89192, MGC127800, ACT-4, DKFZp469E0314, Acta2, asma, acta, cftd, mpfd, nem1, nem2, nem3, acta2, cftd1, cftdm, MGC52636, MGC79039

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

ACTA2 monoclonal antibody (M01), clone 4A8-2H3. Western Blot analysis of ACTA2 expression in human omentum, serous carcinoma. Immunoperoxidase of monoclonal antibody to ACTA2 (AT1030a) on formalin-fixed paraffin-embedded human . [antibody concentration ug/ml]

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (Image 2)

Publications

Product: Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Lin, Cai, Chen et al.: "[Relationship between atrial fibroblast proliferation/fibrosis and atrial fibrillation in patients with rheumatic heart disease]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 9, pp. 813-7, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Adegboyega, Rodriguez, McLarty: "Stromal expression of actin is a marker of aggressiveness in basal cell carcinoma." in: Human pathology, Vol. 41, Issue 8, pp. 1128-37, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).