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Details for Product No. ABIN396199

Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody

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Antigen
Synonyms
AAT6, ACTSA, MYMY5, 0610041G09Rik, Actvs, SMalphaA, a-SMA, alphaSMA, wu:fb63d03, asma, ASMA, SMactin, a-sma, aat6, actsa, mymy5, sm-actin, ACTA2, actc1, ACT-4, acta, cftd, mpfd, nem1, nem2, nem3, acta ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396199
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ACTA2 (AAH17554, 1 a.a. ~ 378 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A8-2H3
Isotype IgG2b kappa
Specificity ACTA2 (AAH17554, 1 a.a. ~ 378 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACTA2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42009 DA
Gene ID 12406
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Lin, Cai, Chen et al.: "[Relationship between atrial fibroblast proliferation/fibrosis and atrial fibrillation in patients with rheumatic heart disease]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 9, pp. 813-7, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Adegboyega, Rodriguez, McLarty: "Stromal expression of actin is a marker of aggressiveness in basal cell carcinoma." in: Human pathology, Vol. 41, Issue 8, pp. 1128-37, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Alternatives for antigen "Actin, alpha 2, Smooth Muscle, Aorta (ACTA2)", type "Antibodies"
Hosts (83), (49), (6), (1)
Reactivities (114), (42), (40), (17), (15), (12), (8), (7), (7), (6), (3), (3), (1), (1), (1), (1)
Applications (75), (73), (38), (37), (33), (15), (13), (12), (10), (7), (5), (2), (2), (2), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (47), (2), (2), (1), (1), (1), (1), (1)
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