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BDH1 antibody (3-hydroxybutyrate Dehydrogenase, Type 1) (AA 1-344)

Details for Product anti-BDH1 Antibody No. ABIN396225, Supplier: Log in to see
Antigen
  • 2310032J20Rik
  • AI327223
  • BDH
  • Bdh
  • SDR9C1
  • zgc:163053
Epitope
AA 1-344
9
5
4
Reactivity
Human
64
26
20
Host
Mouse
44
20
Clonality (Clone)
Monoclonal ()
Conjugate
This BDH1 antibody is un-conjugated
5
4
4
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
47
29
21
11
8
3
1
1
1
Supplier
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Immunogen BDH1 (AAH11964, 1 a.a. ~ 344 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B3
Isotype IgG2a kappa
Specificity BDH1 (AAH11964, 1 a.a. ~ 344 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name BDH1 (BDH1 Antibody Abstract)
Background This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described.
Synonyms: BDH, MGC2723, MGC4347, MGC9788 3-hydroxybutyrate dehydrogenase, type 1
Molecular Weight 38157 DA
Gene ID 622
Research Area Cell Structure, Metabolism
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BDH1 antibody (3-hydroxybutyrate Dehydrogenase, Type 1) (AA 1-344) (ABIN396225) BDH1 monoclonal antibody (M03), clone 4B3. Western Blot analysis of BDH1 expression i...
Background publications Persson, Kallberg, Bray, Bruford, Dellaporta, Favia, Duarte, Jörnvall, Kavanagh, Kedishvili, Kisiela, Maser, Mindnich, Orchard, Penning, Thornton, Adamski, Oppermann: "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative." in: Chemico-biological interactions, Vol. 178, Issue 1-3, pp. 94-8, 2009

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002

Xu, Huang, Xu, Qian, Zhu, Yan, Cai, Zhang, Xiao, Qu, Liu, Huang, Cheng, Li, Du, Hu, Shen, Lu, Fu, Zhong, Xu, Gu, Huang, Zhao, Hu, Gu, Chen, Han: "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 26, pp. 15089-94, 2001

Loeb-Hennard, McIntyre: "(R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain." in: Biochemistry, Vol. 39, Issue 39, pp. 11928-38, 2000