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Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody

Details for Product No. ABIN396238, Supplier: Login to see
Antigen
  • HADHSC
  • hadhsc
  • HADH
  • HAD
  • HADH1
  • HCDH
  • HHF4
  • MSCHAD
  • SCHAD
  • Hadhsc
  • AA409008
  • AU019341
  • AW742602
  • Schad
  • wu:fb66a11
  • zgc:86777
Epitope
AA 205-315
19
13
7
5
5
3
3
3
2
2
1
1
1
1
Reactivity
Human
95
46
45
12
6
2
2
1
1
1
1
Host
Mouse
69
32
17
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
88
34
25
24
23
18
16
6
4
3
3
3
3
Supplier
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Immunogen HADHSC (NP_005318, 205 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B5
Isotype IgG2b kappa
Specificity HADHSC (NP_005318, 205 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HADHSC (HADH Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34278 DA
Gene ID 12406
NCBI Accession NP_005318
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody (ABIN396238) Immunofluorescence of monoclonal antibody to HADHSC on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody (ABIN396238) anti-Hydroxyacyl-CoA Dehydrogenase (HADH) (AA 205-315) antibody (Image 2)
Background publications Kalsi, Kuo, Aliev et al.: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).

Di Candia, Gessi, Pepe et al.: "Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 6, pp. 1019-23, 2009 (PubMed).

van Hove, Hansen, Dekker et al.: "The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study." in: Diabetes, Vol. 55, Issue 11, pp. 3193-6, 2006 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Yang, He, Schulz: "3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease." in: The FEBS journal, Vol. 272, Issue 19, pp. 4874-83, 2005 (PubMed).