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Ghrelin/obestatin Prepropeptide (GHRL) antibody

Details for Product No. ABIN396250
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Antigen
Synonyms MTLRP, 2210006E23Rik, Ghr, MTLRPAP, m46, MTLRP-AP, GRHL, Gh1-1, GHR
Reactivity
Human
(133), (31), (28), (14), (14), (12), (2), (1), (1), (1)
Host
Mouse
(86), (49), (9), (6), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(113), (73), (23), (20), (10), (7), (5), (5), (5), (5), (5), (4), (4), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN396250
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen GHRL (AAH25791, 1 a.a. ~ 118 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B8
Isotype IgG2a kappa
Specificity GHRL (AAH25791, 1 a.a. ~ 118 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GHRL
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12911 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake, however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ghrelin/obestatin Prepropeptide (GHRL) antibody GHRL monoclonal antibody (M09), clone 4B8. Western Blot analysis of GHRL expression in HeLa. Immunoperoxidase of monoclonal antibody to GHRL on formalin-fixed paraffin-embedded human stomach (antibody concentration 1 µg/mL).
anti-Ghrelin/obestatin Prepropeptide (GHRL) antibody (2) anti-Ghrelin/obestatin Prepropeptide (GHRL) antibody (Image 2)
Background publications Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Zhu, Liang, Zou et al.: "Plasma ghrelin levels and polymorphisms of ghrelin gene in Chinese obese children and adolescents." in: Irish journal of medical science, Vol. 179, Issue 3, pp. 345-9, 2010 (PubMed).

Landgren, Jerlhag, Hallman et al.: "Genetic variation of the ghrelin signaling system in females with severe alcohol dependence." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 9, pp. 1519-24, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN396250
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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