Ghrelin/obestatin Prepropeptide (GHRL) (AA 1-118) antibody

Details for Product No. ABIN396250, Supplier: Log in to see
Antigen
  • 2210006E23Rik
  • Ghr
  • MTLRP
  • MTLRPAP
  • m46
  • Gh1-1
  • GRHL
  • MTLRP-AP
  • GHR
  • ghrelin
  • ghrelin-like
  • ghrelin/obestatin preprohormone
  • ghrelin/obestatin prepropeptide
  • Ghrl
  • LOC100349547
  • ghrl
  • GHRL
Alternatives
anti-Human Ghrelin/obestatin Prepropeptide antibody for Cellular Assay
Epitope
AA 1-118
30
19
17
13
11
10
9
9
8
5
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
247
98
74
11
6
3
3
1
1
1
1
Host
Mouse
176
86
20
16
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
24
11
9
7
7
6
6
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
166
125
57
29
27
26
23
11
10
6
4
3
2
2
2
2
2
2
1
1
1
Options
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Immunogen GHRL (AAH25791, 1 a.a. ~ 118 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B8
Isotype IgG2a kappa
Specificity GHRL (AAH25791, 1 a.a. ~ 118 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GHRL (GHRL Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12911 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Pathways Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake, however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ghrelin/obestatin Prepropeptide (GHRL) (AA 1-118) antibody (ABIN396250) GHRL monoclonal antibody (M09), clone 4B8. Western Blot analysis of GHRL expression i...
Immunohistochemistry (IHC) image for anti-Ghrelin/obestatin Prepropeptide (GHRL) (AA 1-118) antibody (ABIN396250) anti-Ghrelin/obestatin Prepropeptide (GHRL) (AA 1-118) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Landgren, Jerlhag, Hallman, Oreland, Lissner, Strandhagen, Thelle, Zetterberg, Blennow, Engel: "Genetic variation of the ghrelin signaling system in females with severe alcohol dependence." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 9, pp. 1519-24, 2010 (PubMed).

Zhu, Liang, Zou, Fu: "Plasma ghrelin levels and polymorphisms of ghrelin gene in Chinese obese children and adolescents." in: Irish journal of medical science, Vol. 179, Issue 3, pp. 345-9, 2010 (PubMed).

Pinheiro, Bulik, Thornton, Sullivan, Root, Bloss, Berrettini, Schork, Kaye, Bergen, Magistretti, Brandt, Crawford, Crow, Fichter, Goldman, Halmi, Johnson, Kaplan, Keel, Klump, La Via, Mitchell, Strober, Rotondo, Treasure, Woodside: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).