Immature Colon Carcinoma Transcript 1 (ICT1) antibody

Details for Product No. ABIN396263
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Antigen
Synonyms DS-1, DS1, 1110001A02Rik, 1110002E03Rik, ICT1
Reactivity
Human
(14), (3), (3), (1)
Host
Mouse
(9), (6)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(14), (7), (2), (1)
Pubmed 5 references available
Catalog no. ABIN396263
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen ICT1 (NP_001536, 107 a.a. ~ 207 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C10
Isotype IgG2a kappa
Specificity ICT1 (NP_001536, 107 a.a. ~ 207 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ICT1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 23630 DA
Gene ID 12406
UniProt NP_001536
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Immature Colon Carcinoma Transcript 1 (ICT1) antibody ICT1 monoclonal antibody (M06), clone 4C10 Western Blot analysis of ICT1 expression in HeLa.
Background publications Suzuki, Yoshitomo-Nakagawa, Maruyama et al.: "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library." in: Gene, Vol. 200, Issue 1-2, pp. 149-56, 1997 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Richter, Rorbach, Pajak et al.: "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome." in: The EMBO journal, Vol. 29, Issue 6, pp. 1116-25, 2010 (PubMed).

Antonicka, Ostergaard, Sasarman et al.: "Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect." in: American journal of human genetics, Vol. 87, Issue 1, pp. 115-22, 2010 (PubMed).

Hosts (9), (6)
Reactivities (14), (3), (3), (1)
Applications (14), (7), (2), (1)
Epitopes (3), (3), (2), (2), (1), (1)
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