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Details for Product No. ABIN396269

beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3) antibody

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Antigen
Synonyms GLCATI, 2810405M13Rik
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396269
Quantity 0.05 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen B3GAT3 (NP_036332, 236 a.a. ~ 336 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C12
Isotype IgG2a kappa
Specificity B3GAT3 (NP_036332, 236 a.a. ~ 336 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name B3GAT3
Background The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.
Synonyms: GLCATI, GlcATIbeta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Molecular Weight 37122 DA
Gene ID 26229
UniProt NP_036332
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.

Restrictions For Research Use only
Concentration 0.39mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Gulberti, Lattard, Fondeur et al.: "Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein l" in: The Journal of biological chemistry, Vol. 280, Issue 2, pp. 1417-25, 2005 (PubMed).

Venkatesan, Barré, Benani et al.: "Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 52, pp. 18087-92, 2004 (PubMed).

Fondeur-Gelinotte, Lattard, Gulberti et al.: "Molecular basis for acceptor substrate specificity of the human beta1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively." in: Glycobiology, Vol. 17, Issue 8, pp. 857-67, 2007 (PubMed).

Tone, Pedersen, Yamamoto et al.: "2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16801-7, 2008 (PubMed).

Alternatives for antigen "beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3)", type "Antibodies"
Hosts (9), (6)
Reactivities (14)
Applications (14), (6), (2)
Epitopes (4), (4), (2), (2), (2), (2)
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