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alpha 1 Adrenergic Receptor antibody (Adrenoceptor alpha 1A) (AA 1-28)

Details for Product anti-ADRA1A Antibody No. ABIN396296, Supplier: Log in to see
Antigen
  • Adra1c
  • ADRA1C
  • ADRA1L1
  • ALPHA1AAR
  • ALPHA-1A
  • alpha-1A
Alternatives
anti-Human alpha 1 Adrenergic Receptor antibody for Immunofluorescence
Epitope
AA 1-28
16
5
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
87
31
28
5
3
3
3
1
1
1
Host
Mouse
66
12
6
3
Clonality (Clone)
Monoclonal ()
Conjugate
This alpha 1 Adrenergic Receptor antibody is un-conjugated
2
2
2
1
1
1
1
Application
Western Blotting (WB)
69
39
17
15
14
6
3
2
1
1
1
1
Supplier
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Immunogen ADRA1A (NP_150646, 1 a.a. ~ 28 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C7
Isotype IgG1 kappa
Specificity ADRA1A (NP_150646, 1 a.a. ~ 28 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ADRA1A (ADRA1A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51487 DA
Gene ID 12406
NCBI Accession NP_150646
Research Area Cell Cycle, Cell Structure
Pathways AMPK Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-alpha 1 Adrenergic Receptor antibody (Adrenoceptor alpha 1A) (AA 1-28) (ABIN396296) ADRA1A monoclonal antibody (M01), clone 4C7 Western Blot analysis of ADRA1A expressio...
Immunohistochemistry (IHC) image for anti-alpha 1 Adrenergic Receptor antibody (Adrenoceptor alpha 1A) (AA 1-28) (ABIN396296) anti-Adrenoceptor alpha 1A (ADRA1A) (AA 1-28) antibody (Image 2)
Background publications Gao, Sakurai, Takeda et al.: "Association between genetic polymorphisms of adrenergic receptor and diurnal intraocular pressure in Japanese normal-tension glaucoma." in: Ophthalmology, Vol. 117, Issue 12, pp. 2359-2364.e1-2, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Herlyn, Müller-Hilke, Wendt et al.: "Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture." in: The Clinical journal of pain, Vol. 26, Issue 3, pp. 175-81, 2010 (PubMed).

Sorrentino, Forleo, Iacoviello et al.: "Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope." in: Autonomic neuroscience : basic & clinical, Vol. 155, Issue 1-2, pp. 98-103, 2010 (PubMed).