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Details for Product No. ABIN396296

Adrenoceptor alpha 1A (ADRA1A) antibody

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Antigen
Synonyms ADRA1C, ADRA1L1, ALPHA1AAR, ALPHA-1A
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396296
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ADRA1A (NP_150646, 1 a.a. ~ 28 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C7
Isotype IgG1 kappa
Specificity ADRA1A (NP_150646, 1 a.a. ~ 28 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ADRA1A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51487 DA
Gene ID 12406
UniProt NP_150646
Research Area Cell Cycle, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Sorrentino, Forleo, Iacoviello et al.: "Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope." in: Autonomic neuroscience : basic & clinical, Vol. 155, Issue 1-2, pp. 98-103, 2010 (PubMed).

Herlyn, Müller-Hilke, Wendt et al.: "Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture." in: The Clinical journal of pain, Vol. 26, Issue 3, pp. 175-81, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Gao, Sakurai, Takeda et al.: "Association between genetic polymorphisms of adrenergic receptor and diurnal intraocular pressure in Japanese normal-tension glaucoma." in: Ophthalmology, Vol. 117, Issue 12, pp. 2359-2364.e1-2, 2010 (PubMed).

Alternatives for antigen "Adrenoceptor alpha 1A (ADRA1A)", type "Antibodies"
Hosts (48), (5), (2)
Reactivities (55), (27), (27), (15), (14), (14), (13), (12), (3), (2), (1), (1), (1), (1), (1)
Applications (38), (29), (11), (10), (10), (8), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (4), (2), (2), (2), (1), (1), (1), (1)
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