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APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) (AA 219-319) antibody

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Synonyms apex1, MGC76280, MGC79645, MGC78928, APE, APE1, APEN, APEX, APX, HAP1, REF1, Apex, REF-1, BAP1, apex1a, hm:zehn1532, wu:fc13d11, zgc:66204, Ref-1
AA 219-319
(29), (10), (6), (6), (6), (4), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(171), (46), (40), (10), (10), (9), (3), (2), (1), (1), (1), (1), (1)
(126), (39), (14)
Clonality (Clone)
Monoclonal ()
(4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(150), (56), (47), (41), (25), (11), (7), (7), (6), (4), (4), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen APEX1 (NP_001632, 219 a.a. ~ 319 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D1
Isotype IgG1 kappa
Specificity APEX1 (NP_001632, 219 a.a. ~ 319 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name APEX1 (APEX1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35555 DA
Gene ID 12406
NCBI Accession NP_001632
Research Area Cell Structure
Pathways DNA Damage Repair
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Palli, Polidoro, DErrico et al.: "Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer." in: Mutagenesis, Vol. 25, Issue 6, pp. 569-75, 2010 (PubMed).

Jelonek, Gdowicz-Klosok, Pietrowska et al.: "Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population." in: Journal of applied genetics, Vol. 51, Issue 3, pp. 343-52, 2010 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Retailleau, Ishchenko, Kuznetsov et al.: "Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 7, pp. 798-800, 2010 (PubMed).

Catalog No. ABIN396306
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