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Cadherin 11 (AA 509-618) antibody

Details for Product No. ABIN396312, Supplier: Log in to see
Antigen
  • Cad11
  • CAD11
  • cad11
  • cadherin-11
  • CDHOB
  • cdhob
  • cdhvn
  • MGC108014
  • OB
  • OB-cadherin
  • OSF-4
  • osf-4
  • vnc
  • Xcad-11
Epitope
AA 509-618
31
20
18
11
11
9
8
7
7
7
4
3
2
2
1
1
1
1
Reactivity
Human
117
20
13
6
6
2
2
1
Host
Mouse
49
41
27
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
5
5
5
5
5
1
Application
ELISA, Western Blotting (WB)
84
71
16
11
7
6
4
4
3
2
1
1
Supplier
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Immunogen CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D10
Isotype IgG2b kappa
Specificity CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDH11
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87965 DA
Gene ID 12406
NCBI Accession NP_001788
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Cadherin 11 (AA 509-618) antibody (ABIN396312) Detection limit for recombinant GST tagged CDH11 is approximately 0.3 ng/mL as a capt...
Background publications Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010

Sachdeva, Mo: "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1." in: Cancer research, Vol. 70, Issue 1, pp. 378-87, 2010

Canova, Hashibe, Simonato, Nelis, Metspalu, Lagiou, Trichopoulos, Ahrens, Pigeot, Merletti, Richiardi, Talamini, Barzan, Macfarlane, Macfarlane, Holcátová, Bencko, Benhamou, Bouchardy, Kjaerheim, Lowry, Agudo, Castellsagué, Conway, McKinney, Znaor, McCart: "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project." in: Cancer research, Vol. 69, Issue 7, pp. 2956-65, 2009

Farina, Bong, Feltes, Byers: "Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells." in: PLoS ONE, Vol. 4, Issue 3, pp. e4797, 2009

Brieger, Duesterhoeft, Brochhausen, Gosepath, Kirkpatrick, Mann: "Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 116, Issue 12, pp. 1050-7, 2009