Cadherin 11 (AA 509-618) antibody

Details for Product No. ABIN396312
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Antigen
Synonyms cad11, cdhob, osf-4, Xcad-11, MGC108014, OB-cadherin, cadherin-11, Cad11, cdhvn, vnc, CAD11, CDHOB, OB, OSF-4
Epitope
AA 509-618
(20), (8), (7), (6), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(89), (31), (22), (19), (19), (17)
Host
Mouse
(50), (33), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(65), (55), (17), (14), (11), (10), (7), (7), (4), (4), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396312
450.00 $
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Immunogen CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D10
Isotype IgG2b kappa
Specificity CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDH11
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87965 DA
Gene ID 12406
NCBI Accession NP_001788
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Cadherin 11 (AA 509-618) antibody Detection limit for recombinant GST tagged CDH11 is approximately 0.3 ng/mL as a capture antibody.
Background publications Brieger, Duesterhoeft, Brochhausen et al.: "Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 116, Issue 12, pp. 1050-7, 2009 (PubMed).

Farina, Bong, Feltes et al.: "Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells." in: PLoS ONE, Vol. 4, Issue 3, pp. e4797, 2009 (PubMed).

Canova, Hashibe, Simonato et al.: "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project." in: Cancer research, Vol. 69, Issue 7, pp. 2956-65, 2009 (PubMed).

Sachdeva, Mo: "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1." in: Cancer research, Vol. 70, Issue 1, pp. 378-87, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

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