Cadherin 11 antibody

Antigen: Cadherin 11

Synonyms: OB, CAD11, CDHOB, OSF-4, cad11, cdhob, osf-4, Xcad-11, MGC108014, OB-cadherin, cadherin-11, cdh11

Clonality: Monoclonal (4D10)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396312

Additional Information

Alternative name: CDH11

Gene ID: 1009

UniProt: NP_001788

Immunogen: CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 4D10

Description: Other names: CAD11, CDHOB, OB, OSF4 cadherin 11, type 2, OB-cadherin (osteoblast)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CDH11 (NP_001788, 509 a.a. ~ 618 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 87965 DA

Comments:

Background: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged CDH11 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Brieger, Duesterhoeft, Brochhausen et al.: "Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 116, Issue 12, pp. 1050-7, 2009 (PubMed).

Farina, Bong, Feltes et al.: "Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells." in: PLoS ONE, Vol. 4, Issue 3, pp. e4797, 2009 (PubMed).

Canova, Hashibe, Simonato et al.: "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project." in: Cancer research, Vol. 69, Issue 7, pp. 2956-65, 2009 (PubMed).

Sachdeva, Mo: "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1." in: Cancer research, Vol. 70, Issue 1, pp. 378-87, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).