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Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) (AA 1-63) antibody

Details for Product No. ABIN396343
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Antigen
Synonyms MAPRE2, DKFZp459O163, EB1, EB2, RP1, AI314113, C820009F03Rik, D18Abb1e, mapre2-A
Epitope
AA 1-63
(9), (8), (7), (3), (3), (2), (1), (1)
Reactivity
Human
(62), (22), (16), (13), (11), (4), (4), (4)
Host
Mouse
(30), (28), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(55), (26), (20), (17), (13), (12), (9), (9), (7), (3)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396343
450.00 $
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Immunogen MAPRE2 (NP_055083, 1 a.a. ~ 63 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D7
Isotype IgG1 kappa
Specificity MAPRE2 (NP_055083, 1 a.a. ~ 63 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAPRE2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37031 DA
Gene ID 12406
UniProt NP_055083
Research Area Cell Signaling, Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown, however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) (AA 1-63) antibody Immunofluorescence of monoclonal antibody to MAPRE2 on HeLa cell (antibody concentration 35 µg/mL). MAPRE2 monoclonal antibody (M03), clone 4D7 Western Blot analysis of MAPRE2 expression in K-562.
anti-Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) (AA 1-63) antibody (2) anti-Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) (AA 1-63) antibody (Image 2)
Background publications Manna, Honnappa, Steinmetz et al.: "Suppression of microtubule dynamic instability by the +TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued." in: Biochemistry, Vol. 47, Issue 2, pp. 779-86, 2008 (PubMed).

Zhu, Gupta, Slabbekoorn et al.: "Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32651-61, 2009 (PubMed).

Abiatari, Gillen, DeOliveira et al.: "The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells." in: International journal of oncology, Vol. 35, Issue 5, pp. 1111-6, 2009 (PubMed).

De Groot, Jelesarov, Damberger et al.: "Molecular insights into mammalian end-binding protein heterodimerization." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5802-14, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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