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Histidine Ammonia-Lyase (HAL) (AA 558-658) antibody

Details for Product No. ABIN396375, Supplier: Log in to see
Antigen
  • hal
  • hstd
  • xhal
  • HAL
  • BA3712
  • PSPTO5099
  • PSPTO5274
  • PSPTO5275
  • DDBDRAFT_0187742
  • DDBDRAFT_0231727
  • DDB_0187742
  • DDB_0231727
  • his
  • Hsd
  • histidase
  • zgc:136980
  • HIS
  • HSTD
Epitope
AA 558-658
5
3
3
3
2
1
Reactivity
Human
19
6
6
2
2
2
2
2
Host
Mouse
11
8
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
19
6
5
3
Supplier
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Immunogen HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F2
Isotype IgG2a kappa
Specificity HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HAL (HAL Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 72698 DA
Gene ID 12406
NCBI Accession NP_002099
Research Area Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Histidine Ammonia-Lyase (HAL) (AA 558-658) antibody (ABIN396375) Western Blot analysis of HAL expression in transfected 293T cell line by HAL monoclon...
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Welsh, Karagas, Applebaum et al.: "A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions." in: Carcinogenesis, Vol. 29, Issue 10, pp. 1950-4, 2008 (PubMed).

Eckhart, Schmidt, Mildner et al.: "Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid." in: Journal of dermatological science, Vol. 50, Issue 3, pp. 209-15, 2008 (PubMed).

Kawai, Moriyama, Asai et al.: "Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene." in: Human genetics, Vol. 116, Issue 5, pp. 340-6, 2005 (PubMed).

Alemán, Ortíz, Langley et al.: "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 289, Issue 1, pp. E172-9, 2005 (PubMed).