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Histidine Ammonia-Lyase (HAL) (AA 558-658) antibody

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Synonyms hal, hstd, xhal, HAL, BA3712, PSPTO5099, PSPTO5274, PSPTO5275, DDBDRAFT_0187742, DDBDRAFT_0231727, DDB_0187742, DDB_0231727, his, Hsd, histidase, zgc:136980, HIS, HSTD
AA 558-658
(5), (3), (3), (3), (2), (1), (1), (1), (1)
(21), (6), (6), (2), (2), (2), (2), (2)
(13), (8)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(21), (6), (5), (3)
Pubmed 5 references available
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Quantity 0.1 mg
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Availability Will be delivered in 8 to 11 Business Days
Immunogen HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F2
Isotype IgG2a kappa
Specificity HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HAL (HAL Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 72698 DA
Gene ID 12406
NCBI Accession NP_002099
Research Area Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Histidine Ammonia-Lyase (HAL) (AA 558-658) antibody (ABIN396375) Western Blot analysis of HAL expression in transfected 293T cell line by HAL monoclon...
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Welsh, Karagas, Applebaum et al.: "A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions." in: Carcinogenesis, Vol. 29, Issue 10, pp. 1950-4, 2008 (PubMed).

Eckhart, Schmidt, Mildner et al.: "Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid." in: Journal of dermatological science, Vol. 50, Issue 3, pp. 209-15, 2008 (PubMed).

Kawai, Moriyama, Asai et al.: "Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene." in: Human genetics, Vol. 116, Issue 5, pp. 340-6, 2005 (PubMed).

Alemán, Ortíz, Langley et al.: "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 289, Issue 1, pp. E172-9, 2005 (PubMed).

Catalog No. ABIN396375
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