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Details for Product No. ABIN396375

Histidine Ammonia-Lyase (HAL) antibody

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Antigen
Synonyms HIS, HSTD, hal, hstd, xhal, zgc:136980, Hsd, his, histidase, HAL, BA3712, PSPTO5099, PSPTO5274, PSPTO5275, DDBDRAFT_0187742, DDBDRAFT_0231727, DDB_0187742, DDB_0231727
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN396375
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F2
Isotype IgG2a kappa
Specificity HAL (NP_002099, 558 a.a. ~ 658 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HAL
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 72698 DA
Gene ID 12406
UniProt NP_002099
Research Area Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Alemán, Ortíz, Langley et al.: "Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 289, Issue 1, pp. E172-9, 2005 (PubMed).

Kawai, Moriyama, Asai et al.: "Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene." in: Human genetics, Vol. 116, Issue 5, pp. 340-6, 2005 (PubMed).

Eckhart, Schmidt, Mildner et al.: "Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid." in: Journal of dermatological science, Vol. 50, Issue 3, pp. 209-15, 2008 (PubMed).

Welsh, Karagas, Applebaum et al.: "A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions." in: Carcinogenesis, Vol. 29, Issue 10, pp. 1950-4, 2008 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Alternatives for antigen "Histidine Ammonia-Lyase (HAL)", type "Antibodies"
Hosts (8), (4)
Reactivities (10), (3), (2), (2), (2), (2), (2), (2)
Applications (11), (4), (4), (3), (2), (1)
Epitopes (3), (2), (2), (2)
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