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LASP1 antibody (LIM and SH3 Protein 1) (AA 1-262)

Details for Product anti-LASP1 Antibody No. ABIN396389, Supplier: Log in to see
Antigen
  • AA408629
  • Def-4
  • fb92f05
  • lasp-1
  • Lasp-1
  • lasp1
  • LASP1
  • MGC53336
  • MGC89667
  • mln50
  • MLN50
  • SH3P6
  • Tg(Col1a1-lacZ)1Ngma
  • wu:fb92f05
  • zgc:77542
Epitope
AA 1-262
32
22
17
13
8
6
3
2
2
2
2
1
1
1
Reactivity
Human
103
21
20
10
6
5
4
4
2
2
1
Host
Mouse
54
39
10
Clonality (Clone)
Monoclonal ()
Conjugate
This LASP1 antibody is un-conjugated
5
5
5
5
5
5
Application
Western Blotting (WB)
97
57
12
6
6
2
2
2
1
1
Supplier
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Immunogen LASP1 (AAH12460, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F5
Isotype IgG2a kappa
Specificity LASP1 (AAH12460, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LASP1 (LASP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29717 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LASP1 antibody (LIM and SH3 Protein 1) (AA 1-262) (ABIN396389) Western Blot analysis of LASP1 expression in transfected 293T cell line by LASP1 mono...
Background publications Frietsch, Grunewald, Jasper, Kammerer, Herterich, Kapp, Honig, Butt: "Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer." in: British journal of cancer, Vol. 102, Issue 11, pp. 1645-53, 2010

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010

Traenka, Hauck, Lewandrowski, Sickmann, Gambaryan, Thalheimer, Butt: "Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase." in: Thrombosis and haemostasis, Vol. 102, Issue 3, pp. 520-8, 2009

Salvi, Bongarzone, Miccichè, Arici, Barlati, De Petro: "Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 2, pp. 207-19, 2009

Wang, Feng, Xiao, Ren: "LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma." in: Journal of hepatology, Vol. 50, Issue 3, pp. 528-37, 2009