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LIM and SH3 Protein 1 (LASP1) antibody

Details for Product No. ABIN396389
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Antigen
Synonyms MLN50, Lasp-1, Def-4, SH3P6, AA408629, Tg(Col1a1-lacZ)1Ngma, fb92f05, zgc:77542, wu:fb92f05, LASP1, DKFZp459O1227, lasp1, MGC53336, MGC89667, mln50, lasp-1
Reactivity
Human
(45), (8), (8), (7), (5), (2), (2), (2), (2), (1)
Host
Mouse
(26), (15), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(47), (27), (7), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN396389
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen LASP1 (AAH12460, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F5
Isotype IgG2a kappa
Specificity LASP1 (AAH12460, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LASP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 29717 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-LIM and SH3 Protein 1 (LASP1) antibody Western Blot analysis of LASP1 expression in transfected 293T cell line by LASP1 monoclonal antibody (M05), clone 4F5. Lane 1: LASP1 transfected lysate(29.7 KDa). Lane 2: Non-transfected lysate.
Background publications Wang, Feng, Xiao et al.: "LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma." in: Journal of hepatology, Vol. 50, Issue 3, pp. 528-37, 2009 (PubMed).

Salvi, Bongarzone, Miccichè et al.: "Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 2, pp. 207-19, 2009 (PubMed).

Traenka, Hauck, Lewandrowski et al.: "Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase." in: Thrombosis and haemostasis, Vol. 102, Issue 3, pp. 520-8, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Frietsch, Grunewald, Jasper et al.: "Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer." in: British journal of cancer, Vol. 102, Issue 11, pp. 1645-53, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN396389
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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