Fatty Acid Binding Protein 3, Muscle and Heart (Mammary-Derived Growth Inhibitor) (FABP3) antibody

Antigen: Fatty Acid Binding Protein 3, Muscle and Heart (Mammary-Derived Growth Inhibitor) (FABP3)

Synonyms: MDGI, FABP11, H-FABP, O-FABP, FABP3, FABP, Mdgi, Fabph1, Fabph4, Fabph-1, Fabph-4, FABP-3

Clonality: Monoclonal (4F6-1D6)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396397

Additional Information

Alternative name: FABP3

Gene ID: 2170

Immunogen: FABP3 (AAH07021, 1 a.a. ~ 134 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 4F6-1D6

Description: Other names: FABP11, HFABP, MDGI, OFABP fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: FABP3 (AAH07021, 1 a.a. ~ 134 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 14858 DA

Comments:

Background: The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Cell Cycle, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of FABP3 over-expressed 293 cell line, cotransfected with FABP3 Validated Chimera RNAi ( Cat # H00002170-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with FABP3 monoclonal antibody (M01), clone 4F6-1D6 (Cat # AT1985a ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Western Blot analysis of FABP3 expression in transfected 293T cell line by FABP3 monoclonal antibody (M01), clone 4F6-1D6. Lane 1: FABP3 transfected lysate(14.9 KDa). Lane 2: Non-transfected lysate.

anti-Fatty Acid Binding Protein 3, Muscle and Heart (Mammary-Derived Growth Inhibitor) (FABP3) antibody (Image 2)

Publications

Product: Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Boscheri, Wunderlich, Langer et al.: "Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk." in: American heart journal, Vol. 160, Issue 2, pp. 294-300, 2010 (PubMed).

Jassim, Fernø, Theisen et al.: "Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia." in: Pharmacopsychiatry, Vol. 44, Issue 1, pp. 15-20, 2011 (PubMed).