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MAD2L1 Binding Protein (MAD2L1BP) (AA 1-275) antibody

Details for Product No. ABIN396419, Supplier: Log in to see
Antigen
  • MAD2L1BP
  • CMT2
  • RP1-261G23.6
  • 0610009D16Rik
  • 2510031P20Rik
  • AU018945
  • AW550977
  • C76045
  • CMT2A
  • CMT2B
  • Mad2lbp
  • mKIAA0110
Epitope
AA 1-275
26
18
5
5
3
1
1
1
1
1
Reactivity
Human
62
10
9
Host
Mouse
47
15
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
54
28
6
6
4
2
1
1
Supplier
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Immunogen MAD2L1BP (AAH02904, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G11
Isotype IgG2a kappa
Specificity MAD2L1BP (AAH02904, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAD2L1BP (MAD2L1BP Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 31052 DA
Gene ID 12406
Research Area Cell Cycle, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAD2L1 Binding Protein (MAD2L1BP) (AA 1-275) antibody (ABIN396419) MAD2L1BP monoclonal antibody (M03), clone 4G11. Western Blot analysis of MAD2L1BP exp...
Background publications Yun, Han, Yoon et al.: "p31comet Induces cellular senescence through p21 accumulation and Mad2 disruption." in: Molecular cancer research : MCR, Vol. 7, Issue 3, pp. 371-82, 2009 (PubMed).

Venkatesan, Rual, Vazquez et al.: "An empirical framework for binary interactome mapping...." in: Nature methods, Vol. 6, Issue 1, pp. 83-90, 2008 (PubMed).

Yang, Li, Tomchick et al.: "p31comet blocks Mad2 activation through structural mimicry." in: Cell, Vol. 131, Issue 4, pp. 744-55, 2007 (PubMed).

Yun, Kim, Park et al.: "Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma." in: Experimental & molecular medicine, Vol. 39, Issue 4, pp. 508-13, 2007 (PubMed).

Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).