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Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 45-155) antibody

Details for Product No. ABIN396435, Supplier: Log in to see
Antigen
  • f3
  • tf
  • AA409063
  • CD142
  • Cf-3
  • Cf3
  • TF
  • TFA
Epitope
AA 45-155
14
12
10
8
6
6
6
5
3
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
146
34
30
16
15
2
2
1
Host
Mouse
89
71
19
8
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
20
18
6
4
3
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
104
99
40
35
16
14
13
11
10
6
4
4
3
2
2
1
1
1
1
1
Supplier
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Immunogen F3 (AAH11029, 45 a.a. ~ 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G4
Isotype IgG2a kappa
Specificity F3 (AAH11029, 45 a.a. ~ 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F3 (F3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33068 DA
Gene ID 12406
Research Area Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 45-155) antibody (ABIN396435) Western Blot analysis of F3 expression in transfected 293T cell line by F3 monoclonal...
Immunohistochemistry (IHC) image for anti-Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 45-155) antibody (ABIN396435) anti-Coagulation Factor III (thromboplastin, Tissue Factor) (F3) (AA 45-155) antibody (Image 2)
Background publications Bouchard, Mann, Butenas: "No evidence for tissue factor on platelets." in: Blood, Vol. 116, Issue 5, pp. 854-5, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).

Zwicker: "Predictive value of tissue factor bearing microparticles in cancer associated thrombosis." in: Thrombosis research, Vol. 125 Suppl 2, pp. S89-91, 2010 (PubMed).