ADA antibody

Antigen: ADA

Clonality: Monoclonal (4G4-1C6)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN396441

Additional Information

Gene ID: 100

Immunogen: ADA (AAH40226, 1 a.a. ~ 364 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 4G4-1C6

Description: Other names: #NAME?

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ADA (AAH40226, 1 a.a. ~ 364 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 40764 DA

Comments:

Background: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Images

ADA monoclonal antibody (M01), clone 4G4-1C6 Western Blot analysis of ADA expression in Jurkat ( Cat # L017V1 ). ADA monoclonal antibody (M01), clone 4G4-1C6. Western Blot analysis of ADA expression in HL-60 ( Cat # L014V1 ).

anti-ADA antibody (Image 2)

Publications

Product: Gloria-Bottini, Banci, Saccucci et al.: "The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease." in: The American journal of the medical sciences, Vol. 340, Issue 2, pp. 103-8, 2010 (PubMed).

Spina, Saccucci, Cozzoli et al.: "A study of three polymorphic sites of ADA gene in colon cancer." in: Cancer investigation, Vol. 28, Issue 10, pp. 989-92, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ri, Ohno, Furutani et al.: "An indication for correlation between the serum ADA level and gastric cancer risk." in: Anticancer research, Vol. 30, Issue 6, pp. 2347-9, 2010 (PubMed).