Adenosine Deaminase (ADA) antibody

Details for Product No. ABIN396441
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Antigen
Synonyms ADA-like, xada, ADA, CG11994, Dmel\\CG11994, DrosADA, dADA, ADGDF-A, ADGF-A, Adgf-a, CG5992, Dmel\\CG5992, adgf-a, adgfa
Reactivity
Human
(45), (38), (20), (19), (12), (1), (1)
Host
Mouse
(63), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(60), (40), (13), (11), (10), (10), (10), (5), (5), (4), (4), (3), (3), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN396441
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen ADA (AAH40226, 1 a.a. ~ 364 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G4-1C6
Isotype IgG1 kappa
Specificity ADA (AAH40226, 1 a.a. ~ 364 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ADA
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40764 DA
Gene ID 12406
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Adenosine Deaminase (ADA) antibody ADA monoclonal antibody (M01), clone 4G4-1C6 Western Blot analysis of ADA expression in Jurkat.
anti-Adenosine Deaminase (ADA) antibody (2) anti-Adenosine Deaminase (ADA) antibody (Image 2)
Background publications Gloria-Bottini, Banci, Saccucci et al.: "The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease." in: The American journal of the medical sciences, Vol. 340, Issue 2, pp. 103-8, 2010 (PubMed).

Spina, Saccucci, Cozzoli et al.: "A study of three polymorphic sites of ADA gene in colon cancer." in: Cancer investigation, Vol. 28, Issue 10, pp. 989-92, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ri, Ohno, Furutani et al.: "An indication for correlation between the serum ADA level and gastric cancer risk." in: Anticancer research, Vol. 30, Issue 6, pp. 2347-9, 2010 (PubMed).

Hosts (63), (12)
Reactivities (45), (38), (20), (19), (12), (1), (1)
Applications (60), (40), (13), (11), (10), (10), (10), (5), (5), (4), (4), (3), (3), (3), (1), (1)
Conjugates (7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (5), (3), (2), (2), (1), (1), (1), (1)
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