Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) antibody

Details for Product No. ABIN396453
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Synonyms dmu, med, mnd2, nmf2, seal, NaCh6, mnd-2, nmf58, nur14, Nav1.6, nmf335, AI853486, C630029C19Rik, CERIII, CIAT, EIEE13, MED, PN4
(26), (18), (18), (13), (12), (12), (2)
(19), (10)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(14), (10), (10), (8), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN396453
Quantity 0.1 mg
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Immunogen SCN8A (NP_055006, 1854 a.a. ~ 1952 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G7
Isotype IgG2a kappa
Specificity SCN8A (NP_055006, 1854 a.a. ~ 1952 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN8A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 225280 DA
Gene ID 12406
UniProt NP_055006
Research Area Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) antibody Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell (antibody concentration 10 µg/mL). SCN8A monoclonal antibody (M04), clone 4G7 Western Blot analysis of SCN8A expression in NIH/3T3.
anti-Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) antibody (2) anti-Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) antibody (Image 2)
Background publications Elia, Capasso, Zaheer et al.: "Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A." in: Psychiatric genetics, Vol. 19, Issue 3, pp. 134-41, 2009 (PubMed).

Chatelier, Zhao, Bois et al.: "Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis." in: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 1, pp. 77-86, 2010 (PubMed).

Meisler, OBrien, Sharkey: "Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects." in: The Journal of physiology, Vol. 588, Issue Pt 11, pp. 1841-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Wang, Zhang, Liu et al.: "Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 11, Issue 8, pp. 956-63, 2010 (PubMed).

Hosts (19), (10)
Reactivities (26), (18), (18), (13), (12), (12), (2)
Applications (14), (10), (10), (8), (3), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (1), (1), (1), (1), (1), (1)
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