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SCN8A antibody (Sodium Channel, Voltage-Gated, Type VIII, alpha) (AA 1854-1952)

Details for Product anti-SCN8A Antibody No. ABIN396453, Supplier: Log in to see
Antigen
  • AI853486
  • C630029C19Rik
  • CERIII
  • CIAT
  • dmu
  • EIEE13
  • med
  • MED
  • mnd-2
  • mnd2
  • NaCh6
  • Nav1.6
  • nmf2
  • nmf58
  • nmf335
  • nur14
  • PN4
  • seal
Epitope
AA 1854-1952
9
4
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
48
27
26
3
2
2
2
2
2
Host
Mouse
32
19
Clonality (Clone)
Monoclonal ()
Conjugate
This SCN8A antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
35
15
11
10
7
6
3
2
1
1
1
Supplier
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Immunogen SCN8A (NP_055006, 1854 a.a. ~ 1952 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G7
Isotype IgG2a kappa
Specificity SCN8A (NP_055006, 1854 a.a. ~ 1952 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN8A (SCN8A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 225280 DA
Gene ID 12406
NCBI Accession NP_055006
Research Area Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SCN8A antibody (Sodium Channel, Voltage-Gated, Type VIII, alpha) (AA 1854-1952) (ABIN396453) Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell (antibody concentr...
Immunohistochemistry (IHC) image for anti-SCN8A antibody (Sodium Channel, Voltage-Gated, Type VIII, alpha) (AA 1854-1952) (ABIN396453) anti-Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) (AA 1854-1952) antibody (Image 2)
Background publications Wang, Zhang, Liu, Shao, Wei, Li, Ji, Yang, Wang, Liu, Wan, Li, Xu, Feng, He, He: "Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 11, Issue 8, pp. 956-63, 2010 (PubMed).

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Meisler, OBrien, Sharkey: "Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects." in: The Journal of physiology, Vol. 588, Issue Pt 11, pp. 1841-8, 2010 (PubMed).

Chatelier, Zhao, Bois, Chahine: "Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis." in: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 1, pp. 77-86, 2010 (PubMed).

Elia, Capasso, Zaheer, Lantieri, Ambrosini, Berrettini, Devoto, Hakonarson: "Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A." in: Psychiatric genetics, Vol. 19, Issue 3, pp. 134-41, 2009 (PubMed).

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