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ERAP1 antibody (Endoplasmic Reticulum Aminopeptidase 1) (AA 832-942)

Details for Product anti-ERAP1 Antibody No. ABIN396490, Supplier: Log in to see
Antigen
  • MGC166160
  • DKFZp469C044
  • ARTS-1
  • A-LAP
  • ALAP
  • APPILS
  • ARTS1
  • ERAAP
  • ERAAP1
  • PILS-AP
  • PILSAP
  • Arts1
  • PILSA
  • Appils
Epitope
AA 832-942
18
6
5
2
2
1
1
1
1
1
1
1
Reactivity
Human
59
19
18
1
1
1
Host
Mouse
56
3
Clonality (Clone)
Monoclonal ()
Conjugate
This ERAP1 antibody is un-conjugated
1
Application
Western Blotting (WB)
34
21
18
16
7
2
1
1
1
1
Supplier
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Immunogen ARTS-1 (AAH30775, 832 a.a. ~ 942 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4H8
Isotype IgG1 kappa
Specificity ARTS-1 (AAH30775, 832 a.a. ~ 942 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ARTS-1 (ERAP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 107235 DA
Gene ID 12406
Research Area Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension (MIM 145500). Adipocyte-derived leucine aminopeptidase (ALAP) is a member of the M1 family of zinc metallopeptidases.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ERAP1 antibody (Endoplasmic Reticulum Aminopeptidase 1) (AA 832-942) (ABIN396490) ARTS-1 monoclonal antibody (M01), clone 4H8 Western Blot analysis of ARTS-1 expressio...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Haroon, Tsui, Chiu et al.: "Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms." in: The Journal of rheumatology, Vol. 37, Issue 9, pp. 1907-10, 2010 (PubMed).

Georgiadou, Hearn, Evnouchidou et al.: "Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1584-92, 2010 (PubMed).

Kamphausen, Kellert, Abbas et al.: "Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma." in: Cancer immunology, immunotherapy : CII, Vol. 59, Issue 8, pp. 1273-84, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).