Pre-B Lymphocyte 3 (VPREB3) (AA 24-124) antibody

Details for Product No. ABIN396497
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Antigen
Synonyms 8HS-20, Vpreb-3, AI528709, VPREB3, 8HS20, N27C7-2
Epitope
AA 24-124
(3), (2), (2)
Reactivity
Human
(10), (1), (1), (1)
Host
Mouse
(4), (3), (3)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(8), (8), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN396497
450.00 $
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Immunogen VPREB3 (NP_037510, 24 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4H8
Isotype IgG1 kappa
Specificity VPREB3 (NP_037510, 24 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VPREB3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 13710 DA
Gene ID 12406
NCBI Accession NP_037510
Research Area Cell Structure, Metabolism
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Pre-B Lymphocyte 3 (VPREB3) (AA 24-124) antibody Western Blot analysis of VPREB3 expression in transfected 293T cell line by VPREB3 monoclonal antibody (M08), clone 4H8. Lane 1: VPREB3 transfected lysate(13.7 KDa). Lane 2: Non-transfected lysate.
Background publications Rosnet, Blanco-Betancourt, Grivel et al.: "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 10228-36, 2004 (PubMed).

Collins, Wright, Edwards et al.: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Rangel, McKeller, Sims-Mourtada et al.: "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript." in: The Journal of biological chemistry, Vol. 280, Issue 18, pp. 17807-14, 2005 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

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