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Pre-B Lymphocyte 3 (VPREB3) (AA 24-124) antibody

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Synonyms 8HS-20, Vpreb-3, AI528709, VPREB3, 8HS20, N27C7-2
AA 24-124
(6), (3), (2), (2), (2), (1)
(25), (3), (3), (2), (1), (1), (1), (1)
(13), (7), (5)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(20), (13), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen VPREB3 (NP_037510, 24 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4H8
Isotype IgG1 kappa
Specificity VPREB3 (NP_037510, 24 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VPREB3 (VPREB3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 13710 DA
Gene ID 12406
NCBI Accession NP_037510
Research Area Cell Structure, Metabolism
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Pre-B Lymphocyte 3 (VPREB3) (AA 24-124) antibody (ABIN396497) Western Blot analysis of VPREB3 expression in transfected 293T cell line by VPREB3 mo...
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Rangel, McKeller, Sims-Mourtada et al.: "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript." in: The Journal of biological chemistry, Vol. 280, Issue 18, pp. 17807-14, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Collins, Wright, Edwards et al.: "A genome annotation-driven approach to cloning the human ORFeome." in: Genome biology, Vol. 5, Issue 10, pp. R84, 2004 (PubMed).

Rosnet, Blanco-Betancourt, Grivel et al.: "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 10228-36, 2004 (PubMed).

Catalog No. ABIN396497
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