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Neighbor of BRCA1 Gene 1 (NBR1) (AA 2-97) antibody

Details for Product No. ABIN396554, Supplier: Log in to see
Antigen
  • fa99f08
  • wu:fa99f08
  • MGC69008
  • NBR1
  • 1A1-3B
  • M17S2
  • mKIAA0049
  • Ca125
  • RGD1311421
Epitope
AA 2-97
8
7
3
2
2
2
1
Reactivity
Human
30
9
6
1
Host
Mouse
17
14
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
28
13
7
5
2
1
1
1
1
Supplier
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Immunogen NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5C3
Isotype IgG2a kappa
Specificity NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name NBR1 (NBR1 Antibody Abstract)
Background The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
Synonyms: KIAA0049, M17S2, MIG19 neighbor of BRCA1 gene 1
Molecular Weight 107432 DA
Gene ID 4077
NCBI Accession NP_005890
Research Area Cancer, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Neighbor of BRCA1 Gene 1 (NBR1) (AA 2-97) antibody (ABIN396554) Western blot analysis of NBR1 over-expressed 293 cell line, cotransfected with NBR1 V...
Immunohistochemistry (IHC) image for anti-Neighbor of BRCA1 Gene 1 (NBR1) (AA 2-97) antibody (ABIN396554) anti-Neighbor of BRCA1 Gene 1 (NBR1) (AA 2-97) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Mardakheh, Yekezare, Machesky et al.: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, 2009 (PubMed).

Waters, Marchbank, Solomon et al.: "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover." in: FEBS letters, Vol. 583, Issue 12, pp. 1846-52, 2009 (PubMed).

Kirkin, Lamark, Johansen et al.: "NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets." in: Autophagy, Vol. 5, Issue 5, pp. 732-3, 2009 (PubMed).

Kirkin, Lamark, Sou et al.: "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." in: Molecular cell, Vol. 33, Issue 4, pp. 505-16, 2009 (PubMed).