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Neighbor of BRCA1 Gene 1 (NBR1) antibody

Details for Product No. ABIN396554
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Antigen
Synonyms Ca125, RGD1311421, 1A1-3B, M17S2, mKIAA0049, fa99f08, wu:fa99f08, MGC69008, NBR1
Reactivity
Human
(14), (5), (3)
Host
Mouse
(8), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(15), (9), (4)
Pubmed 5 references available
Quantity 0.05 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN396554
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5C3
Isotype IgG2a kappa
Specificity NBR1 (NP_005890, 2 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name NBR1
Background The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
Synonyms: KIAA0049, M17S2, MIG19 neighbor of BRCA1 gene 1
Molecular Weight 107432 DA
Gene ID 4077
UniProt NP_005890
Research Area Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca
Expiry Date 6 months
Supplier Images
anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody Western blot analysis of NBR1 over-expressed 293 cell line, cotransfected with NBR1 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of NBR1 expression in transfected 293T cell line by NBR1 monoclonal antibody (M05), clone 5C3. Lane 1: NBR1 transfected lysate(107.4 KDa). Lane 2: Non-transfected lysate.
anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody (2) anti-Neighbor of BRCA1 Gene 1 (NBR1) antibody (Image 2)
Background publications Kirkin, Lamark, Sou et al.: "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." in: Molecular cell, Vol. 33, Issue 4, pp. 505-16, 2009 (PubMed).

Kirkin, Lamark, Johansen et al.: "NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets." in: Autophagy, Vol. 5, Issue 5, pp. 732-3, 2009 (PubMed).

Waters, Marchbank, Solomon et al.: "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover." in: FEBS letters, Vol. 583, Issue 12, pp. 1846-52, 2009 (PubMed).

Mardakheh, Yekezare, Machesky et al.: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN396554
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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