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F2RL3 antibody (Coagulation Factor II (Thrombin) Receptor-Like 3) (AA 18-83)

Details for Product anti-F2RL3 Antibody No. ABIN396605, Supplier: Log in to see
Antigen
  • AA408040
  • F2
  • F2RL3
  • Lkb1
  • mLKB1
  • Par-4
  • PAR4
  • R75140
Epitope
AA 18-83
13
13
10
8
6
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
99
44
42
3
2
1
1
1
1
Host
Mouse
86
12
1
Clonality (Clone)
Monoclonal ()
Conjugate
This F2RL3 antibody is un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
54
33
23
22
17
9
5
3
2
1
1
1
Supplier
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Supplier Product No.
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Immunogen F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5F4
Isotype IgG1 kappa
Specificity F2RL3 (NP_003941, 18 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name F2RL3 (F2RL3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41133 DA
Gene ID 12406
NCBI Accession NP_003941
Research Area Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-F2RL3 antibody (Coagulation Factor II (Thrombin) Receptor-Like 3) (AA 18-83) (ABIN396605) Detection limit for recombinant GST tagged F2RL3 is approximately 0.03 ng/mL as a cap...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Ramstrom, ONeill, Dunne, Kenny: "Annexin V binding to platelets is agonist, time and temperature dependent." in: Platelets, Vol. 21, Issue 4, pp. 289-96, 2010

Chen, Tsou, Tsai, Kuo, Chiang, Chang, Fong, Tang: "Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 737-45, 2010

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009

Megyeri, Makó, Beinrohr, Doleschall, Prohászka, Cervenak, Závodszky, Gál: "Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 5, pp. 3409-16, 2009